Antioxidant system state in blood of pigs under the conditions of RESPIRATORY DISEASES and application of medicinal products Flovet 30% and Floricol

V. P. Muzyka

muzyka@scivp.lviv.ua

State scientific research control institute of veterinary medicinal products and feed additives, Donets’ka st., 11, Lviv, 79019, Ukraine

It was determined that respiratory diseases of agricultural animals characterize the tension in the system of antioxidant protection and activation of peroxidation processes, as a result in organs there is an accumulation of oxidation toxic products that possess cytotoxic, genotoxic, mutational and oncogenic effect. Enzymatic link of antioxidant protection system and the intensity of lipoperoxidation processes in pigs that suffer from lung diseases and also under the conditions of Flovet 30% and Floricol application were studied. The animals from control group were given the medicinal product Flovet 30% and treated one Floricol in identical doses. On the 1st, 7th and 15th day of treatment the activity of superoxide dismutase, glutathione peroxidase and catalase in whole blood and hydroperoxide lipid content, diene conjugates and TBA-active products in blood plasma were determined. It was determined that blood of sick animals on the 1st day of treatment is characterized by low activity of tested enzymes and high content of lipoperoxidation products in control and treated groups. The application of Flovet 30% and Floricol allowed increasing the activity of antioxidant enzymes and slowing down the process of lipid peroxidation. During the whole period of treatment the content of tested peroxidation products in blood plasma of sick animals that were given Flovet 30% was higher. Taking into account the fact that higher activity of antioxidant enzymes was registered in control in comparison with treated one, one can conclude that Floricol is more effective in the treatment of respiratory diseases.

Keywords: pigs, respiratory diseases, lipid peroxidation, antioxidant system, Flovet, Floricol

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