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THE STATE OF THE SYSTEM OF ANTIOXIDANT DEFENCE OF PREGNANT COWS UNDER CONDITIONS OF TECHNOGENIC LOADING AND ACTION OF CORRECTING FACTORS

N. A. Broda1, D. I. Mudrak1, O. I. Vishchur1, M. I. Ratskiy1, 
N N. Leshovska1,
I. Y. Solovodzinska2 

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1Institute of Animal Biology NAAS; 38 V. Stus St, Lviv, 79034, Ukraine

2Lviv National AgrarianUniversity, 1 V. Velikogo St, Dubliany, Lviv region,

80381, Ukraine

Viability and resistance of new-born calves highly depend on efficiency of functioning of the immune and antioxidant systems of cows, especially in a last period of pregnancy. This causes the actuality of developments of new immuno-trophyc remedies with antioxidant and immuno-modulating properties with the aim of increase of immuno-biological reactivity of organism of cows and their calves.

The research was held on two groups of cows in the last month of pregnancy which according to the analogues principle were divided into control and experimental groups of 5–7 animals in each and calves born from them. The cows of the research group at 30 and 14 days before the anticipated calving were intramuscularly injected by liposomal drug which is composed of tocopherol acetate, squalene, lecithin, L-methionine, L-arginine, sodium selenite, oil from the fruit of milk thistle, flax seed and sea buckthorn dose 0.04 ml per kg of body weight.

It was established that the cows of the control group that were in the zone of technogenic loading, induced by coal mining system for 14 days before calving in the blood, increase the content of lipid hydroperoxides and TBA-active products (p<0.05).

Two-times parenteral injection of liposomal emulsion in the cows in the last month of their pregnancy leads to a reduction of lipid hydroperoxides and TBA-active products for 14 and 7 days before calving compared to the control group of animals (p<0.050,01). In the calves derived from them in the 3rd night of their life are seen lower levels of TBA-active products (p<0.05). The cows of experimental group compared to the cows of control group set higher content of reduced glutathione in erythrocytes at all stages of the research and higher glutathione plasma activity for 7 days before delivery (p<0.05). The calves of experimental group have glutathione content in erythrocytes greater than in animals of the control group (p<0.05).

Keywords: COWS, CALVES, HEAVY METALS, SYSTEM of ANTIOXIDANT DEFENCE, TBA-ACTIVE PRODUCTS, LIPID HYDROPEROXIDES, REDUCED GLUTATHIONE,GLUTATHIONE ACTIVITY, BIOLOGICALLY ACTIVE SUBSTANCES

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