Bìol. Tvarin, 2018, volume 20, issue 4, pp. 69–73

METABOLISM OF NITROGEN COMPOUNDS IN THREE GENERATIONS OF RATS UNDER THE INFLUENCE OF GLYPHOSATE-RESISTANT GENETICALLY MODIFIED SOY AND ROUNDUP HERBICIDE

I. V. Chorna1, G. V. Dronyk2

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1National Technical University “Kharkiv Polytechnic Institute”,
2 Kirpichova str., Kharkiv 61002, Ukraine

2Bukovyna State Agricultural Experimental Station NAAS,
21 Bohdana Kryzhanivskoho str., Chernivtsi 58026, Ukraine

The article presents the results of the study of the effect of traditional, glyphosate-resistant genetically modified soybeans and the “Roundup” herbicide on the content of total protein, urea, uric acid and creatinine in blood serum of three generations of rats. Organophosphorus fertilizers are toxic substances that can lead to a metabolic disorder, therefore the study of the influence of genetically modified soybean treated with herbicide and the “Roundup” herbicide on the level of nitrogen metabolites in the animal organism is very relevant.

The research has been conducted on the rats of the Wistar line which were divided into five groups: 1st control group — intact group; 1st experimental group — 20–26 % of the feed in the diet of rats were replaced with traditional soy; 2nd experimental group — 20–26 % of the feed in the diet were replaced with genetically modified soy which had not been treated with the “Roundup” herbicide; 3rd experimental group — rats were fed genetically modified soy which had been treated with a herbicide; 4th experimental group — the rats received “Roundup” herbicide with drinking water. 42 days after the commencement of feeding traditional and genetically modified soy, the females of all groups were mated and continued to receive the same diet and herbicide in drinking water.

These studies have shown that the use of a diet containing traditional and genetically modified soy which had not been treated with the “Roundup” herbicide leads to a slight increase in the nitrogen compounds level in the blood. Analysis of the results in other groups showed that using genetically modified soy which had been treated with the herbicide and watering the herbicide leads to an increase of the protein, urea, uric acid and creatinine level in three generations of rats; only in the IV group there was a slight decrease in urea in the first and subsequent generations.

Such results may indicate the toxic effects of herbicide and transgenic soybeans treated with the “Roundup” herbicide and disorders of the liver and kidney of rats.

Keywords: TRADITIONAL AND TRANSPLANTIC SOYA, GENETICALLY MODIFIED ORGANISMS, SKIN, CREATININ, LAYER ACID, NITROGEN EXCHANGE, GENERAL PROTEIN

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