Bìol. Tvarin, 2016, Volume 18, Issue 2, pp. 73–79



A. Z. Pylypets, О. Z. Svarchevska, O. M. Buchko, L. I. Ponkalo

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Institute of animal biology NAAS,
38 Vasyl Stus str., Lviv 79034, Ukraine

The article presents the study of lipid metabolism in comparing the actions of citrate salts, trace elements and micronutrients inorganic acids in the blood plasma of pigs lets.

The study was conducted in 3 groups of piglets analogs at 10-day age (control and two experimental) with 10 animals in each group. Pigs of first experimental group received a basic diet and inorganic salts premix with Iron (1500 mg/kg), Zinc (1100 mg/kg), Manganese (1100 mg/kg), Copper (1550 mg/kg), Cobalt (10 mg/kg). The second experimental group consumed the main diet and premix where minerals salts of inorganic acids were replaced with micronutrients citrate in 10 times lower concentration, which included: Fe — 150 mg; Zn — 110 mg; Mn — 110 mg; Cu — 155 mg; Co — 1 mg.

It was found that lipid metabolism in the piglets fed with citrate micronutrients intensified compared to control animals and animals treated with minerals salts of inorganic acids used in conventional premixes.

Feeding citrate micronutrients helped to reduce non-etherified cholesterol and increase triacylglycerols contents in blood plasma of pigs at 28 and 45 days of life compared to control animals and animals treated with salts of inorganic acids.

The results indicate that additives in the form of citrate micronutrients have more significant effect on activation of lipid metabolism in the body of piglets in II experimental group at 28 and 45 days of age compared to the addition of inorganic salts trace elements which used for pigs in I research group. This can be explained by better bioavailability of citrate and their influence on the regulation of lipid metabolism.

Further research in this area allows to prevent of pathological changes in different organs and tissues of pigs connected with microelementosis and to develop effective measures to enhance the adaptive capacity of animals.


1. Skalnyiy A. V., Rudakov I. A. Bioelements in medicine. M., Onyx 21st Century, 2004, 272 p. (in Russian)
2. Gulich M. P.The problems of micronutrient deficiency in the diet of modern man, ways to overcome. Eating a factor of public health: abstracts. ext. Intern. saens. Pract. Conf., K., 2003, 45 p. (in Ukrainian)
3. Storozhok N. M. The biological effect of the macro- and micronutrients: Manual (for students), 2006, 24 p. (in Russian)
4. Shih E. V., Ramenskaya G. V., Syichev D. A. Contact pharmacokinetics pharmacodynamics. Clinical Pharmacology. 2005, vol. 4, no. 4, pp. 12–19. (in Ukrainian)
5. Zozulyak V. I. The biological role and daily balance of trace elements (copper, iron, chromium, manganese, zinc, lithium, cadmium) in the body of healthy people and patients with tuberculosis destructive. Ukrainian pulmonology journal, 1994, no. 1, pp. 40–42. (in Ukrainian)
6. Bratushko Yu. I., Yatsimirskiy K. B. Coordination compounds of 3D transition metals with molecular oxygen. Russian Chemical coordination compounds. Kyiv, Nauk. dumka, 1975, pp. 7–71. (in Ukrainian)
7. Tsypriyan V. I. Kuzminska O. V. Nutritional factors of iron deficiency among women of childbearing age. Eating a factor of public health: abstracts. ext. Intern. nauk. and practical. Conf. Kyiv, 2003, 89 p. (in Ukrainian)
8. Chekman I. S. Magnesium drugs: pharmacological properties, application. Zaporizhzhya-Kyiv, 2007, 123 p. (in Ukrainian)
9. Panchenko L. F., Maev I. V., Gurevich K. G. Clinical chemistry of trace elements. Moscow, 2004, 368 p. (in Russian)
10. Kates M. Techniques of lipidology. Amsterdam, Elsevier, 1986, 451 р.
11. Klimov A. N., Nikulicheva N. G. Exchange of lipids and lipoproteins and its on-fracture: a guide for physicians. St. Petersburg, Peter Com, 1999, p. 512. (in Russian)
12. Lewis R. N. A. H., McElhaney R. N. Surface charge markedly attenuates the nonlamellar phase-forming properties of lipid bilayer membranes: calorimetric and 31P-nuclear magnetic resonance studies of mixtures of cationic, anionic, and zwitterionic lipids. Biophys. J, 2000, Vol. 79, no. 3, pp. 1455–1464. https://doi.org/10.1016/S0006-3495(00)76397-1
13. Gulik-Krzywicki T. Structural studies of the associations between biological membrane components. Comp. Biochem. Physiol, 1995, vol. 105, no. 1, pp. 161–214.
14. Bahlay O. M., Murska S. D., Hutyy B. F., Hufriy D. F. Antioxidant system and lipid peroxidation of animals. Scientific Messenger of LNUVMB named after S. Z. Gzhytsky, 2011, vol. 13, no 4 (50), part 2, pp. 3–11. (in Ukrainian)

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