The influence of antiparasitic medicinal product Closaverm-A on some biochemical blood indices of cows suffering  from mixed invasion

O. L. Tishyn, K. O. Vysots’ka-Kalyniuk

State Scientific Research Control Institute of Veterinary Medicinal Products

and Feed Additives, Donetska str., 11, Lviv, 79019, Ukraine

The aim of work was to study the influence of medicinal product Closaverm-A on some biochemical blood indices suffering from mixed invasion. The cows with body weight 450–550 kgwere used in the test. Before administration of medicinal product the cows were examined by means of scatoscopy method of consecutive flushings for the presence of fasciola eggs and Fulleborn’s method for the presence of eggs of intestinal nematodes. The intensiveness of invasion was detected by means of Trach’s method. The control group contained animals without helminth eggs, cows suffering from mixed invasion were divided into two experimental groups. The cows from one experimental group were administered antiparasitic medicinal product Closaverm-A intramuscularly in the dose of 0.5 ml on 10 kg of body weight. On the 14th and 21st day after administration of medicinal product the blood was collected from jugular vein and the biochemical test were conducted due to generally accepted methods for studying of the influence of Closaverm-A on the organism.

On the 14th and 21st day after administration of medicinal product Closaverm-A the signs of activity strengthening of asparagine aminotransferase on the background of low activity of alkaline phosphatase were detected. Such changes in activity of abovementioned blood enzymes could be associated with disorders of heart and liver activity on the background of intoxication caused by helminthes and the influence of anrtiparasitic medicinal product. The cows treated with Closaverm-A showed disappearance of helminthes and improvement of metabolism in comparison with untreated animals that showed increase of β-, γ- and α2-globulin number that indicated function disorder of liver associated with invasion.

Keywords: Closaverm-A, cows, mixed invasion, BIOCHEMICAL BLOOD TESTS, total protein, ALBUMINS, GLOBULINS, ASPARTATE AMINOTRANSFERASE, ALANINE AMINOTRANSFERASE, ALKALINE PHOSPHATASE

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