BILE ACIDS IN ORGANISMS OF HEALTHY AND SICK NEWBORN CALVES AND AFTER APPLYING ENTEROSORBENTS

V. A. Tomchuk

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National University of Life and Environmental Sciences of Ukraine,

HeroivOboronyst., 15, Kiev, 03041, Ukraine

Taking into consideration the crucial role of bile acids in the processes of digestion and assimilation of feed components of lipid nature, intermediate metabolism of bile acids in the body of newborn calves suffering from dyspepsia was investigated.

Analysis of the data shows that in calf's bile appear differences of the ratio of individual bile acids and a significant decrease in their total content. Seven fractions of conjugated and free bile acids, including the dominated taurocholic, taurohenodesoksicholic, taurodezoksichoic, hlikocholic acid are identified. It was found that on the background of reduction of bile acids conjugated with taurine and glycine in gallbladder bile and liver of newborn calves suffering from acute indigestion, the level of free bile acids increases significantly. This indicates a decrease in biosynthetic and conjugating liver function of patients with dyspepsia in calves. In addition, the increasing toxic litocholic acid. Analysis of extracts from the colon diseased calves showed that the total content of bile acids significantly increased. This indicates that the body of sick animals lose large amounts of the compounds and the significant variations in entnrohepatycal cycle of the gastrointestinal tract.

Inthebileandthecontents of thecoloninpatientscalvesserumtotalbilirubin significantlyincreased. Thus, itscontentinbile of patients calves 1.2 timesgreaterthaninthecontrol, andthecontents of thecolonisalmosttwicethecontrolvalue. Thesedataindicatethatthebodyofsickcalvesundertheinfluence of certainfactors, includingelevatedlevels of LHA, intensifiedhemoglobin break downsimultaneouslywiththereduction of the term of erythrocytes half-life.

Apply for therapeutic purposes enterosorbents partially or fully stabilize certain level of bile-acid metabolism in the body of experimental animals and most of their recovery.

Keywords: BILE ACIDS, BILE, NEWBORN CALVES, ENTEROSORBENTS

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