THE IMPACTONMETIFEN ON ANTIOXIDANT AND IMMUNE DEFENSE SYSTEM OF PIGLETS UNTER NITRATE POISONG

C. J. Leskiv, D. F. Gufrij

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Lviv National University of Veterinary Medicine and Biotechnologies

named afterS.Z.Gzhytsky, Pekarska st., 50, Lviv, 79010

The aim of study was to investigate and analyze the dynamic parameters of the antioxidant system and the resistance of pigs, in nitrate-nitrite load. The experiment was conducted on pigs of large white breed three month old. The material for the study were blood samples. In the blood by known methods were defined: the total number of T-lymphocytes in general, phagocytic activity, the intensity of phagocytosis. Inserum were investigated: the glutathione peroxidase activity, catalase activity, superoxide dismutase, lysocym active of serum, the bactericidal activity of serum content of circulating immune complexes of high molecular weight.

We found the antioxidant effect of Metifen which was feed at a dose of 0.9 mg/kgm.w. The positive effects of this remedy under antioxidant and immune system in nitrate loading has been established. In our studies it was shown by the growth performance of the level enzymatic antioxidant system namely, superoxide dismutase, glutathione peroxidase and catalaseand increased resistance of the body piglets.Conduct of the study made it possible to further explore the impact of nitrates and nitrites in the body of pigs and make appropriate amendments to the concept of mechanisms of chronic nitrate-nitrite toxicity animals with regard to the status of the antioxidant system and the immune system.

Keywords: ANTIOXIDANTSYSTEM, METIFEN, NITRATE-NITRITELOAD

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