THE INFLUENCE OF METIFEN AND VITAMIX-SE OF ENZYME SYSTEM OF ANTIOXIDANT DEFENSE OF BULLS ORGANISM AT CHRONICAL NITRATE AND NITRITE TOXICOSIS WITH CADMIUM LOADING

N. V. Nazaruk, D.F. Hufriy

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Lviv National University of Veterinary Medicine and Biotechnology named after S. Z. Gzhytsky,
50 Pekarska St., Lviv, 79010

The article deals with the results of search of the influence of sodium nitrate and cadmium chloride on enzyme system indices of antioxidant defense in young cattle, namely on the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase. It was set up, that bulls feeding with sodium nitrate in dose 0.15 gr NO3/kg of the living body mass and cadmium chloride in dose 0.02 mg/kg of the living body mass, the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in the blood of experimental animals during the whole experiment was decreased. The activity of system enzyme of antioxidant defense in blood of young cattle was the lowest on the twentieth day of experiment, which is connected with the intensified activation of lip peroxidation and balance violation between the activity of antioxidant system and the intensity of per oxidative lipids oxidation. Under the conditions of chronically nitrate-nitrite toxicosis with cadmium loading, complex preparation with antioxidant action «Metifen», which consists of fenaron and methionine, and also the preparation «Vitamix-Se», which consists of Vitamin E and sodium selenite. It was found out the stimulated influence of preparations on the activity of antioxidant defense system. Particularly, it was set up the credible rise of the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in blood of young cattle, which were carried into nitrate-cadmium loading. The defined changes are taken place thanks to the complex action of the preparation contents «Metifen» and «Vitamix-Se» that leads to the normalization of metabolic and free-radical processes in bull’s organism. Got search results indicate about the antioxidant action of the preparation «Metifen» and «Vitamix-Se» while using them by young cattle and about the provement of their introduction with the purpose of organism antioxidant status rise at chronically nitrate-nitrite toxicosis with cadmium loading.

Keywords: ANTIOXIDANT SYSTEM, «METIFEN», «VITAMIX-SE», CATALASE. SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE, GLUTATHIONE REDUCTASE, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, BULLS

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