TOXICOLOGICAL EVALUATION OF LORATADINE ON LABORATORY ANIMALS

A. B. Kuzminov

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Lviv national medical university of Danylo Halytskyy,
Pekarska str 69, Lviv, 79010, Ukraine

2nd generation antihistamine loratadine is producing by chemical and pharmaceutical companies in Ukraine, which causes the development of hygienic standard of acceptable content in the working area of industrial premises .

Toxicity parameters of loratadine were determined on laboratory animals under conditions of acute and subchronic toxicological experiments. In studies were used non-linear white rats, white mices and rabbits. Loratadine was administered orally, intranasally, applied to the skin and mucous membranes

Duration of acute experiments was 14 days, subchronic 24 days.

Revealed that loratadine is moderately hazardous substance. Median lethal doses for laboratory animals are 1980 mg/kg to 6150 mg/kg. Absolutely lethal dose of loratadine for rats is 10,000 mg/kg, for mices 4000 mg/kg.Symptoms of a lesion central nervous system dominated in the clinical picture of acute poisoning.Death of animals stretched in time, comes from the first day of the experiment, and is caused by acute heart failure with pulmonary edema and hyperemia. In other internal organs found signs of acute circulatory failure.In animals, that survived, the general condition was normalized on the 4th day.The is an insignificant risk of acute oral poisoning over calculated values.

Skin-resorptive and local irritant effects in skin contact are absent.

Loratadine has medium expressed locally irritant effect in contact with the mucous membranes of eyes.

Under administration of increasing doses, loratadine shows strong cumulative activity with the development of the clinical picture of subchronic intoxication.

Keywords: LORATADINE, PARAMETERS OF TOXICITY, ABSORPTIVE TOXIC EFFECT, LOCAL IRRITANT EFFECT, CUMULATIVE PROPERTIES

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