synthesis of cortisol and aldosterone IN the suprarenals  of rabbits With acute arginine pancreatitis and its correction

O. O. Hopanenko

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Institute for AgricultureCarpathianNational Academyof Agricultural Sciences,
5, Hrushevskyi St.,Obroshyno, Lviv region, 81115, Ukraine

Aim of the study was to determine the level of cortisol and aldosterone depending on the content and fatty acid composition of esterified cholesterol in the blood plasma of rabbits with acute arginine pancreatitis and with acute arginine pancreatitis corrected by linseen oil. The explorationconducted on male rabbits breed Gray Giant body weight 3.84.0 kg during 30 days. The material for the study were blood samples. Cortisol and aldosterone in plasma were determined by using imunoenzyme test systems company «Immunodiagnostic»(Germany). The concentrations of esterified cholesterol were determined in the blood plasma by chromatography in a thin layer of silica gel.

Feeding with linseed oil in the diet of rabbits leads to an increased level of cortisol and aldosterone in the blood plasma of rabbits with acute arginine pancreatitis. The content of esterified cholesterol increases in the blood plasma of rabbits with the above disease. Feeding with linseed oil leads to normalization of esterified cholesterol in the blood plasma of rabbits with acute arginine pancreatitis. In the fatty acid composition of esterified cholesterol the relative level of saturated fatty acids with odd and even number of carbon atoms in the chain and monounsaturated fatty acids ω-7 and ω-9 families increases, but polyunsaturated fatty acids ω-3 and ω-6 families decreases in the blood plasma of rabbits with the above disease. In the fatty acid composition of esterified cholesterol in the blood plasma of rabbits with acute arginine pancreatitis, corrected by linseen oil, relative amount of monounsaturated fatty acids ω-9 family decreases, but polyunsaturated fatty acids ω-3 family increases.

Keywords: rabbits, pancreatitis, correction, blood, cortisol, aldosterone, esterified cholesterol, fatty acid composition

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