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MORPHOLOGICAL AND CYTOGENETIC CHANGES IN BLOOD CELLS FOR HORSES ANAPLASMOSIS BABESIOSIS INVASION

M. P. Prus1, P. P. Dshus2, N. S. Perehinyak1

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1National University of Life and Environmental Sciences of Ukraine, Heroyiv Oborony st., 15, Kyiv,03041

2Institute of Animal Breeding and Genetics National Academy of Sciences of Ukraine, Pogrebnyak, 1 st., p. Chubinskoe, Boryspil district, Kiev region

For the first time in Ukraine conducted a comprehensive diagnostic study of horses. Investigated hematological and cytogenetic changes in blood parameters Ukrainian horse breed horses on their own modifications. The features of clinical-morphological changes in horses with AnaplasmosisBabesiosis —invasion, blood parasite infestation animal disease pathogens (Babesia caballi, Babesia equi and Anaplasma phagocytophilum (Ehrlichia equi)), depending on age. Statistical processing of the results of research that has allowed to analyze the dynamics of morphological parameters of blood of infected animals before and after treatment, animal carriers compared with the control group. The dependence of the frequency of clinical manifestations in mixed infestations of age, the virulence of pathogens, the reactivity of animals. The highest recorded invasion pathogens in horses 12-years. The differences in the dynamics of the number of red blood cells, white blood cells and hemoglobin at different duration and severity. Fixed increased number of monocytes and lymphocytes in the blood of animals of experimental groups. In infested animals spontaneously noted a sharp decline in the number of red blood cells and hemoglobin, except for the carriers. However, after the treatment of horses and animals of carrier hemoglobin decreased more slowly and quickly rebuilt. Horses on the adjacent invasion agents hematozoons found violations of genetic homeostasis, is shown elevated levels of cells with micronuclei, quantitative karyotype violations by type of aneuploidy and increased the frequency of formation of chromatid fragments. According to the results of cytogenetic analysis assessed the level of somatic variation in Ukrainian horse breed horses on the adjacent blood parasite invasion of pathogens diseases. It is recommended to conduct a comprehensive cytogenetic monitoring horses in danger of invasion of pathogens blood parasite diseases.

Keywords: HORSES, MORPHOLOGY OF BLOOD, CYTOGENETIC INDICATORS, MICRONUCLEI, STRUCTURAL ABERRATIONS, ANAPLASMOSIS, BABESIOSIS

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