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THE INFLUENCE OF «AMPROLINSYL» AND BROVITACOCYDE ON THE INDICES OF CELLULAR AND HUM ORAL IMMUNITY OF TURKEYS BY EMERIES AND HISTOMONOSE INVASION

I. I. Khariv

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Lviv national university of veterinary medicine and biotechnologies named after S. Z. Gzhytskyj, 79010, Lviv, Pekarska str., 50

The articke deals with the results of studies of the effect of anti-eymeriozic preparation of «Amprolinsyl» and brovitacoccides on the indices of cellular and humoral immunity of turkeys for eymeriozic and histomonozic invasion, namely the number of leukocytes, lymphocytes, T-lymphocytes, B-lymphocytes, lizocymic and bactericidal activity of blood serum, the level of circulating immune complexes and seromucoides. Brovitacoccides is a highly effective means of anti-eimeriozic action. Because of eymeria and histomonad death negative effects of toxins is stopped on the immune system of turkeys which were treated with brovitacoccides. However, brovitacoccides even in therapeutic doses has immune-depressive action that we found in experiments on intact turkey. Therefore, the immune system of turkeys treated with the above mentioned drug, is recovering slowlier and not completely. Rapid and complete recovery of the functional state of the immune system in turkeys infected with eymeriozic and histomonozic invasion was found at feeding of turkeys with «Amprolinsyl» containing hydrochloric amprolium (active ingredient of brovitacoccides) and powdered fruits of milk thistle. Fruits contain a group flavolignates under the title «Silymarin», which have immunostimulatory action at the immunodeficiency state of organism. At the same time, «Silymarin» acts as haepatoprotector and enhances protein synthesis, including immune gamma globulin. It blocks the excessive lipid peroxidation and protects cell membranes against aggressive oxygen species, which provides to the high mentioned preparation, the high antioxidant action. Therefore, the restoration of the functional state of cellular and humoral immunity, follows on a period of clinical turkeys recovery (on the fifth day of treatment).

Keywords: PHARMACOLOGY, CELLULAR AND HUMORAL IMMUNITY, TURKEY, BROVITACOCCIDE, «AMPROLINSYL», EIMERIA, HISTOMONADE, BACTERICIDAL AND LIZOCIMIC ACTIVITY, BLOOD, T-1 B-LYMPHOCYTES

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