Bìol. Tvarin, 2019, volume 21, issue 4, pp.71–74

EFFECTS OF TETRACYCLINE INJECTION ON BLOOD CALCIUM AND RUMINAL ACTIVITY IN SHEEP

P. Mudroň

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University of Veterinary Medicine and Pharmacy in Košice, clinic of ruminants,
73 Komenského, Košice 04181, Slovak Republic

Tetracycline is widely used in the treatment of the foot rot in ruminants. It chelates with Ca2+ ions causing a depression of levels of ionised calcium. The objective of the study was to assess effects of tetracycline administration on serum calcium concentrations and the frequency of ruminal contractions. Rumen contractions were monitored by auscultation in 23 sheep prior to administration of oxytetracycline and recorded every 12 hours for 84 hours after intramuscular injection of the antibiotic. Blood for calcium analyses was collected by venepuncture of the jugular vein before and 24, 48, 72, and 96 hours after administration of oxytetracycline. The serum calcium concentrations were determined by atomic absorption spectrophotometry. Analysis of variance (ANOVA) was used to analyse the time effect of tetracycline treatment on the rumen contractions and serum calcium concentrations. There was a significant decrease (P<0.01) in ruminal contractions following application of oxytetracycline, with a maximum decrease at 24 hours following oxytetracycline application and a return to the initial rumen contraction frequency by 60–72 hours following oxytetracycline application. The oxytetracycline administration resulted in serum calcium decrease from 2.42 mmol/l to 2.26 mmol/l 24 hours after the administration (P<0.01). In conclusion, as found in our study the administration of tetracycline in sheep can be associated with a decline in ruminal motility potentially causing production losses, particularly in lactating ewes.

Keywords: CALCIUM, TETRACYCLINE, RUMEN ACTIVITY

  1. Agwuh K. N., MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. Journal of Antimicrobial Chemotherapy, 2006, vol. 58, issue 2, pp. 256–265. https://doi.org/10.1093/jac/dkl224
  2. Bengtsson B., Franklin A., Luthman J., Jacobsson S.-O. Concentrations of sulphadimidine, oxytetracycline and penicillin G in serum, synovial fluid and tissue cage fluid after parenteral administration to calves. Journal of Veterinary Pharmacology and Therapeutics, 1989, vol. 12, issue 1, pp. 37–45. https://doi.org/10.1111/j.1365-2885.1989.tb00639.x
  3. Colvin H. W., Digesti R. D., Louvier J. A. Effect of succulent and nonsucculent diets on rumen motility and pressure before, during and after eating. Journal of Dairy Science, 1978, vol. 61, issue 10, pp. 1414–1421. https://doi.org/10.3168/jds.S0022-0302(78)83743-6
  4. Ebashi S. Calcium ion and muscle contraction. Nature, 1972, vol. 240, pp. 217–218. https://doi.org/10.1038/240217a0
  5. Hara S., Ikegaya Y., Jørgensen R. J., Sasaki J., Nakamura M., Tomizawa N. Effect of induced subclinical hypocalcemia on the motility of the bovine digestive tract. Acta Veterinaria Scandinavica, 2003, vol. 44, suppl. 1, article no. P76. https://doi.org/10.1186/1751-0147-44-S1-P76
  6. Ibsen K. H., Urist M. R. Complexes of calcium and magnesium with oxytetracycline. Proceedings of the Society for Experimental Biology and Medicine, 1962, vol. 109, issue 4, pp. 797–801. https://doi.org/10.3181/00379727-109-27339
  7. Neuvonen P. J. Interactions with the absorption of tetracyclines. Drugs, 1976, vol. 11, issue 1, pp. 45–54. https://doi.org/10.2165/00003495-197611010-00004
  8. Strobel H., Lauseker M., Forbes A. B. Targeted antibiotic treatment of lame sheep with footrot using either oxytetracycline or gamithromycin. VetRecord,2014, vol. 174, issue 2, p. 46. https://doi.org/10.1136/vr.101840
  9. Sunagawa K., Arikawa, Higashi M., Matsuda H., Takahashi H., Kuriwaki Z., Kojiya Z., Uechi S., Hongo F. Direct effect of a hot environment on ruminal motility in sheep. Asian-Australasian Journal of Animal Sciences, 2002, vol. 15, issue 6, pp. 859–865. https://doi.org/10.5713/ajas.2002.859
  10. Takagi H., Block E. Effects of reducing on calcium kinetics dietary cation-anion balance in sheep. Jomnal of Dairy Science, 1991, vol. 74, issue 12, pp. 4225–4237. https://doi.org/10.3168/jds.S0022-0302(91)78618-9
  11. Tsuda T. Digestion and absorption. In: Animal Physiology. by T. Tsuda. Youkendo, Tokyo, 1994, pp. 161–162.
  12. Wassink G. J., Grogono-Thomas R., Moore L. J., Green L. E. Risk factors associated with the prevalence of footrot in sheep from 1999 to 2000. VetRecord, 2003, vol. 152, issue 12, pp. 351–358. https://doi.org/10.1136/vr.152.12.351
 

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