Bìol. Tvarin, 2019, volume 21, issue 2, pp. 73–76

QUANTITATIVE INSULIN SENSITIVITY CHECK INDEXES IN EARLY POSTPARTUM COWS AND CALVES KEPT IN A BEEF SUCKLER SYSTEM

L. Vranković1, J. Aladrović1, I. Pipal2, B. Beer Ljubić3, N. Prvanović Babić4, Z. Stojević1

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1University of Zagreb, Faculty of Veterinary Medicine, Department of Physiology and Radiobiology,
Heinzelova ul., 55, Zagreb, 10000, Croatia
2Veterinary clinic VETMED d.o.o., 
Gornje Selo 59, Stružec, Popovača, 44317, Croatia
3University of Zagreb, Faculty of Veterinary Medicine, Internal Diseases Clinic, 
Heinzelova ul., 55, Zagreb, 10000, Croatia
4University of Zagreb, Faculty of Veterinary Medicine, Reproduction and Obstetrics Clinic,
Heinzelova ul., 55, Zagreb, 10000, Croatia

The aim of our study was to determine indexes of insulin resistance (IR) in early postpartum period in cows and their calves kept in a beef suckler system. The study was conducted on 13 Simmental cows and their calves. We calculated following indexes values: RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) and its modified version RQUICKIBHB, HOMA (Homeostatic Model Assessment) and QUICKI (Quantitative Insulin Sensitivity Check Index) based on serum concentrations of glucose, insulin, NEFA (non esterified fatty acids) and BHB (β-hydroxybutyrate), sampled 6, 12 and 48h and 7 and 14 d pp. Cows were grouped according to lactation number (2nd to 4th lactation, 1st group; and 5th to 8th lactation, 2nd group) and calves according to gender.

Results showed that RQUICKI was higher in 1st group of cows (P>0.05) and showed progressive increase during pp period in both groups. In 1st group of cows RQUICKI was lower 6 and 12 h pp than 14 d p.p. (P=0.01). HOMA was higher in 2nd group of cows (P>0.05); HOMA was higher 12 h pp than 48 h, 7 and 14 d p.p. (P=0.01) as well as 6 h pp than 7 and 14 d p.p. (P=0.01). QUICKI showed the same trend in both groups, progressive decrease from 6h to 14 d p.p. (P=0.001, 1st group; P=0.001, 2nd group). In calves, HOMA was higher in females (P>0.05). In females HOMA was lower 6 h pp than 7 and 14 d p.p. (P=0.03). RQUICKIBHB was higher in females than in males (P=0.03). RQUICKIBHB showed progressive decline from 6 h p.p. to 14 d p.p. in females (P=0.004). Changes in trends of IR indexes may help in analysis of decreased sensitivity or responsiveness to the metabolic actions of insulin as well as in determination of metabolic status of animals.

Keywords: COWS, CALVES, EARLY POSTPARTUM PERIOD, INSULIN RESISTANCE, BEEF SUCKLER SYSTEM

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