Bìol. Tvarin, 2015, volume 17, issue 3, pp. 117–123

THE INFORMATIVENESS OF BIOCHEMICAL MARKERS CONTENT IN SERUM AT REPTILES METABOLIC OSTEOPATHY

G. O. Stepanenko

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Kharkiv State Zooveterinary Academy,
v. Mala Danilovka, Dergachi district, Kharkiv region, 62341, Ukraine

In this article the informativeness of biochemical markers of connective tissue status (glycoproteins, general chondroitinsulfates, fractions of glycosaminoglycans — chondroitin-6, -4- and keratansulfates) is submitted in different reptiles families at metabolic osteopathy. There were calculated the indexes for these tests of informativeness and grounded their values for assessment of the reptiles health at metabolic ostheopathy. On the base of this data it was found, that informativeness of calcium is 83.3 %, phosphorus — 100 %, alkaline phosphatase — 58.3 %, total chondroitinsulfates and glycosaminoglycans — 100 %, chondroitin-6-sulfate — 75% chondroitin-4-sulfate — 91.7 %, keratansulfates — 100 % in iguanas with metabolic osteopathy. Informativeness is 77.8 % for calcium, phosphorus — 55.6%, alkaline phosphatase and uric acid — 50 %, total chondroitinsulfates, glycosaminoglycans, chondroitin-6-sulfate and keratansulfates — 100 %, chondroitin-4-sulfate — 87.5 % at metabolic osteopathy in agamas. Increased uric acid level and AST activity in the serum of agamas with metabolic osteopathy testify about the development of endogenous intoxication in these reptile’s families and about more severe disease compared to iguanas. Thus, it was found that connective tissue diagnostic tests for metabolic osteopathy at iguans and agamas have been compared with traditional biochemical indicators in blood serum — calcium, phosphorus, total protein, activity of ALT, AST and alkaline phosphatase, urea, uric acid. We plan to create a diagnostic scheme for studying of reptiles metabolic osteopathy involving biochemical markers of connective tissue status for its assessment and subsequent correction.

Keywords: REPTILE, CONNECTIVE TISSUE, BIOCHEMISTRY, GLYCOPROTEINS, CHONDROITIN SULFATES, GLYCOSAMINOGLYCANS, INFORMATIVENESS

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