ACTIVITY OF ENZYME IN COWS SERUM BLOOD AT MYCOBACTERIOSIS AND FASCIOLOSIS ASSOCIATION

O.Kulyaba

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Lviv National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytskyj,
50 Pekarska Str., Lviv 79010, Ukraine

The article deals with the results of research of fasciolosis and mycobacteriosis influence on the activity of enzymes in cows blood serum.The aminotransferaseactivity determinationin serum has an important prognostic meaning in clinical practice of veterinary medicine, as they are on the bound of the metabolism of proteins, fats and carbohydrates. As it has been shown from the results of research the aminotransferase activity at associations of fasciolosis and mycobacteriosis in blood serum of cows was increased. The increased activity of aminotransferases because of damaged biological cell membranes, caused by fasciola and mycobacteria, is released from hepatocytes and cardiac muscle in the blood of intracellular enzymes: alanine and aspartate aminotransferase. The deeper structural damage cells biological membranes, the higher the level of serum transaminases.

By the given activation of free radical oxidation, has the importance meaning of functional activity of intracellular defense systems, which, in the first place belongs to the antioxidant defense system, represented a set of specialized enzymes antioxidants. The state of antioxidant system at fasciolosis and mycobacteriosis was evaluated by the activity of blood enzymes: catalase and superoxide dismutase. It was established that at the development of fasciolosis and mycobacteriosis in cows the activity of catalase and superoxide dismutase is decreases respectively to 23% (CT) and 28% (SOD). In our experiments it is set up changes in the activity of catalase and superoxide dismutase in blood serum of experimental cows reveal additional aspects of toxic effects of fasciola and of mycobacteria and may be used as criteria for evaluating not only the assessment of the body, but also the medical effectiveness of antidote drugs for these diseases.

Key words:PARASITOLOGY, MICROBIOLOGY, COWS, FASCIOLOSIS, MYCOBACTERIOSIS, ANTIOXIDANT SYSTEM, ENZYMES, AMINOTRANSFERASE

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