THE INFLUENCE OF SELENIUM AND GERMANIUM ON SEPARATE LINKS OF PATHOGENESIS OF GASTROENTERITIS OF CALVES

G. A. Zinko, L. G. Slivinska

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Lviv National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytskyj, Pekarska str., 50, Lviv, 79010, Ukraine

The research was conducted on calves 1.5–2 months of age. Animals were divided into 3 groups (control clinically healthy, two experimental sick with gastroenteritis).

Treatment of first and second experimental groups were performed using amoxicillin 15% LA, and Tryvitamini solution containing sodium chloride, sodium bicarbonate and glucose. Calves of the second experimental group except of the basic treatment were additionally injected subcutaneously with Germanium Maksydin 0.4 and orally given the selenium in preparation Sel-Plex.

In the serum of calves sick with gastroenteritis was established hyperproteyinemiya (in 40 % of animals), increased content of TBA-active products (p<0.001); molecules of average weight (p<0.01) and reduction of SH-groups (p<0.001), increased activity of aspartate aminotransferase (p <0.001) and alanine aminotransferase (p<0.001).

The use of preparations of selenium and germanium in the second experimental group in treatment of calves for gastroenteritis contributed to normalization of TBA-active products, total protein content, the average weight molecules (IMS), circulating immune complexes (CIC), reduction of the number of SH-groups and decrease of aminotransferases serum. The normalization of indices of animals in the 1st experimental group during treatment was less evident.

In the group of calves which were applied only basic treatment clinical recovery occurred on 7–8 day, and in the group of animals which were additionally given drugs of selenium and germanium symptoms of gastroenteritis disappeared on 5–6 day of treatment.

When the effectiveness of two schemes of treatment of calves suffering from gastroenteritis were compared, it was found that the use of drugs Sel-Plex and Maksydin 0.4 in treatment of calves for gastroenteritis is more effective than conventional therapy.

Keywords:CALVES, GASTROENTERITIS, SELENIUM, GERMANIUM, AMINOTRANSFERASES, MIDDLE MASS MOLECULES, TOTAL PROTEIN, SH-GROUPS

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