Bìol. Tvarin, 2019, volume 21, issue 1, pp. 40–47

TOXICODYNAMICS OF BROMINE IN RATS UNDER AN ACUTE POISONING WITH SODIUM BROMIDE

O. L. Orobchenko, M. Y. Romanko, Y. M. Koreneva, O. T. Kutsan

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National Scientific Center “Institute of Experimental and Clinical Veterinary Medicine”,
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The spectrum of environmental impacts of inorganic origin toxicants, trace elements, in particular, on the cellular, systemic and organism levels mostly depends on the concentration of the toxic substance exposure duration and the previous health condition of the animals and their immunological reactivity. It has been found for today that mechanisms and the rate of trace elements penetration through various biological barriers and selective accumulation depends not only on their physical and chemical properties and chemical composition, but also on the conditions of the internal environment of the microorganism. One of such element is Bromine. The article presents the results of experimental studies of Bromine toxicodynamics parameters in rats under an acute poisoning with sodium Bromide at a dose of 37.0 (1/100 DL50) and 370.0 mg/kg (1/10 DL50) of the body weight (by Bromine).

It has been found that with a single oral administration of sodium bromide at a dose of 370.0 mg/kg of the body weight the total hemoglobin reducing (16.1 %), the amount of proteinograms indicators (by reducing of the total protein and its albumin function on average of 13.5 and 13.5 %) and nonspecific immune resistance (due to the decrease of circulating immune complexes formation by 13.4 % and the rising of serumkoids by 20.7 %), and also hypoglycemia (17.1%) and hypofermentemia of both aminotransferases (due to a decrease of the ALT and AST activity by 8.0 and 13.8 %; 8,2 and 10.3 %; Р<0.05) were registered in the rats blood just on the end of the experiment (7th and 14th day). Thus, the mechanism of toxic action of Bromine in rats was characterized by redirection of metabolic reactions the prevalence of catabolic processes over anabolic along with the loss of structural and energy resources and is dose-dependent. Considering a single injection of a toxicant and a degree of explored indicators deviation, I can assume that as a result of adaptation processes in the animal body, it is possible to restore such parameters to the physiological level in future. However, conducting further research on the parameters of toxicodynamics in the conditions of chronic (prolonged) receipt of Bromine in the organism of laboratory and productive animals is relevant today.

Keywords: RATS, BROMINE, DOSES, CLINICAL AND BIOCHEMICAL MARKERS, TOXICODYNAMICS, POISONING

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