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Bìol. Tvarin, 2018, volume 20, issue 4, pp. 26–33

THE EFFECT OF SILICON COMPOUNDS ON RESISTANCE OF THE RABBITS

A. I. Ivanytska, Ya. V. Lesyk, M. M. Tsap

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Institute of Animal Biology NAAS,
38 V. Stus str., Lviv 79034, Ukraine

In the presented material, the results of the 14-day fertilization study and up to 20 days of lactation for the silicon citrate obtained by the method using nanotechnology, calculated from 50 μg Si/kg body weight and metasilicate of sodium in the amount of 2.5 mg Si/kg of weight body on indicators of resistance of their organism. Resistance indices were studied on the 10th day of the preparatory period and on the 20th day of lactation of the rabbits (65 days of supplements). The research has established the significant (P<0.01–0.001) intergroup differences in the relative content of phagocyte activity of neutrophils, bactericidal and lysozyme activity in blood of rabbits on the 20th day of lactation, which was emitted by organic and inorganic silicon citrate compounds, indicating the stimulatory effect of Silicon on cellular and humoral links of non-specific resistance of their organism.

The content of hexoses bound to proteins and ceruloplasmin in the blood of animals of the Іst and ІІnd experimental groups respectively increased by 37.7 and 22.0 % (P<0.05) and 18.2 and 13.7 % (P<0.01–0.001) on 65th day of the study compared with the control group. The indicated changes within the limits of physiological quantities in the blood testify to the activation of immune-physiological protection systems in the body of the rabbits during the period of increased physiological load. The less pronounced effect on the content of sialic acids in the body of the rabbits was noted by the action of metasilicate sodium, but the organic compound of silicon was marked by a stimulatory effect on their concentration.

The results of the study of the content of glycoproteins and their carbohydrate components in the blood are confirmed by a higher concentration of immunoglobulins. The use of citrate silicon resulted in a significant increase (P<0.05) of the content of immunoglobulins in the blood of the rabbits of the experimental group at 65 days of study compared with the control. This indicates the stimulatory effect of Si citrate on the synthesis of certain classes of immunoglobulins in the lymphatic system, which regulates the mechanisms of immunity.

Kerwords: RABBITS, SILICON CITRATE, SODIUM METASILICATE, RESISTANCE, IMUNOGLOBULINS, GLUCOPROTEINS

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