Bìol. Tvarin, 2017, volume 19, issue 4, pp. 58–63             

http://doi.org/10.15407/animbiol19.04.059

ANALYSIS OF THE DYNAMICS OF ANTIBODY SYNTHESIS IN HORSE SERUM AFTER VACCINATION WITH UA-07 “ANTRAVAK” AGAINST ANTHRAX OF BACILLUS ANTHRACIS STRAIN

A. Rublenko1, V. G. Skripnik2

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1Bila Tserkva National Agrarian University,
126 Stavyschanska str., Bila Tserkva 09117, Ukraine

2National Research Institute laboratory diagnostics and veterinary and sanitary examination,
30 Donetska str., Kyiv 03151, Ukraine

The results of research to determine the level of antibody titer of anthrax in horses of all ages after a vaccine against anthrax strain of animals Bacillus anthracis UA07 “Antravak” are presented in the paper. For the research three groups of horses were formed. All research groups of animals received vaccine at a dose of 1.0 cm3. The animals which received saline instead of the vaccine were used as control. The aim of research was to study the dynamics of anthrax formation of antibodies in the serum of horses immunized with the new vaccine against anthrax of domestic animals with a strain of Bacillus anthracis UA07 “Antravak”. Dynamics of changes was determined by individual selection and study of serum samples by indirect clumping together red blood cells. Animals differed in age, which probably led to different results in antibody synthesis.

The presence of antibody titers to the pathogen Bacillus anthracis horses was established in all age groups of experimental animals. As a result of clinical trials it was found that a vaccine against anthrax strain of animals Bacillus anthracis UA07 “Antravak” was well tolerated by animals without causing adverse reactions. With the introduction of the recommended dose and route of administration a significant increase of antibodies in horses of 3rd group compared to other groups and control was noted.

According to the research it was found that the vaccine strain of anthrax animals Bacillus anthracis UA07 “Antravak” leads to higher antibody titers of anthrax, especially in older animals. The lowest level of antibody synthesis was noted in the 1st group with the least age of animals.

Keywords: ANTHRAX, DISTRIBUTION, VACCINES, EQUINE, CREDITS, ANTIBODIES, BACILLUS ANTHRACIS, “ANTRAVAK”

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