UDC 577.1:619                                                              http://dx.doi.org/10.15407/animbiol18.04.098

GLUTATHIONE-RELATED ENZYMES OF LIVER AND CAECUM OF ANIMALS

O. M. Fedets, I. M. Kurliak, R. S. Dankovych

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Stepan Gzhytsky Lviv National University
of Veterinary Medicine and Biotechnologies,
50 Pekarska str., Lviv 79010, Ukraine

The activities of glutathione S-transferase, glutathione peroxidase and glutathione reductase and the concentration of glutathione in liver and mucosa of caecum of cattle, guinea pig, horse, pig, rabbit and sheep have been investigated and compared.

Major differences were observed between the tested animals. The activity of glutathione S-transferase and level of glutathione were significantly higher in animals’ liver than in caecum. In liver the activity of glutathione S-transferase in order from high to low was as follows: sheep> rabbit > guinea pig > horse > pig > cattle. In caecum glutathione S-transferase activity was the highest in rabbit. In liver the level of glutathione was the highest in sheep and it was the lowest in cattle. The activity of glutathione peroxidase was significantly higher in liver of rabbit and pig than in their caecum. The lowest data were in both organs of horse. It was not detected in caecum of guinea pig. The activity of glutathione reductase was higher in animals’ caecum than in liver. The enzyme activity was higher in the liver only in the guinea pig.

The differences were significant in cattle, pig and horse but not in rabbit and guinea pig. The enzyme activity was similar in caecum of cattle and pig. The significant difference was between rabbit and horse. The investigations should be carried out on all animal species.

Keywords: GLUTATHIONE, GLUTATHIONE TRANSFERASE, GLUTATHIONE PEROXIDASE, GLUTATHIONE REDUCTASE, LIVER, CАECUM

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