Bìol. Tvarin, 2016, Volume 18, Issue 3, pp. 30–35

http://dx.doi.org/10.15407/animbiol18.03.030

EVALUATION OF MORPHOFUNCTIONAL STATE OF TURKEY IMMUNE ORGANS IN CLINICAL TRIALS OF THE PREPARATION “BIOTON”

М. Zhyla

zhyla-m@ ukr.net

State Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives,
11 Donetska str., Lviv 79019, Ukraine

The article presents macro- and microscopic description of organs of the immune system and indexes of the productivity of turkeys at the clinical trials of new veterinary preparation “Bioton” which contains a complex of biologically active products of metabolism of mushrooms-endophytes, extracted from the roots of medical plants.

For the investigation of unconcern and efficiency of application of veterinary preparation “Bioton” 3 groups of turkeys of cross “Big-6” were formed with 25 heads in each group. The 1st group was given preparation in a dose of 1 ml/l, the 2nd group — in a dose 2 ml/l of water during 7 days in 1st, 6th, 15th and 21st week of fattening. The 3rd group did not receive preparation (control). During carrying out the test no deviations in behavior and clinical state of turkeys and no diseases appeared. The dynamics of change of body weight was determined by the individual weekly weighing.

The macroscopic structure of the investigated immune organs of turkeys was preserved in all groups. Weight coefficients of thymus, bursa of Fabricius were credibly higher in turkeys of the 2nd group. By histological research of the immune system organs of turkeys which were given preparation “Bioton” with water the deceleration of processes of age-old involution of thymus and bursa of Fabricius was established while in the control group the reduction of sizes of thymus particles and increase of area of interlobular connective tissue, atrophy of lymphoid tissue in bursa of Fabricius and reduction of white pulp and sizes of lymph nodes in spleen were revealed.

As a result of clinical trials it was established that preparation “Bioton” was well carried by the poultry and did not cause by-reactions. When used in the recommended dose, method and multiplicity of application it assisted the improvement of metabolic processes and morphofunctional stateof thymus, bursa of Fabricius and spleen in comparing to the control group.

Keywords: TURKEYS, BIOTON, CLINICAL TRIALS, ORGANS OF THE IMMUNE SYSTEM, PATOMORPHOLOGICAL INVESTIGATIONS

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