Bìol. Tvarin, 2016, Volume 18, Issue 2, pp. 68–72

http://dx.doi.org/10.15407/animbiol18.02.068

COMPARISON OF EXCITATORY AND INHIBITORY AMINO ACIDS PLASMA SPECTRUM IN PATIENTS WITH PRIMARY CEREBRAL ISCHEMIC STROKE DEPENDING ON THE POSTAPOPLECTIC SPASTICITY DEVELOPMENT IN THE RECOVERY PERIOD

A. V. Payenok1, M. S. Bilobryn1, N. V. Kuzmina2, I. M. Mitelman1

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1 Danylo Halytsky Lviv National Medical University,
69 Pekarska str., Lviv 79010, Ukraine

2 Institute of Animal Biology NAAS,
38 V. Stus St., Lviv 79034, Ukraine

Post-stroke spasticity is one of the most common post-stroke conditions that survivors face during their recovery. Spasticity can be painful and significantly impact a survivor’s life. The reasons of its phenomenon are not completely understood.

We investigated plasma concentrations of the excitatory and inhibitory neuro amino acid’s during first 72 hours of the first-ever ischemic cerebral stroke survivors (45 patients) depending on the development of post-stroke spasticity in those patients on the 6th month after stroke onset. Plasma level of the same neuro amino acids in people with chronic cerebral ischemia served as a control.

We have found that the joint characteristic for both groups of stroke survivors (those who developed spasticity and those who did not) was significantly increased level of excitatory neuro amino acids cmpared to control. In the group of patients without post-stroke spasticity an elevated excitatory neuro amino acid level was accompanied by an increased concentration of inhibitory neuromediators. But there was a distinguishing feature for stroke survivors with spastic limbs which was characterized by decreased or unchanged levels of inhibitory neuro amino acids.

Thus, such result suggests that an insufficiency of inhibitory neuro amino acid system activation is some acute ischemic stroke patients who are subsequently prone to an emergence of post-stroke spasticity. This study needs further investigations in order to determine the metabolic or neuro-biochemical reasons of the observed difference between two groups of patients. Besides, we can use obtained results for creating the post-stroke spasticity predictive model for ischemic cerebral stroke survivors.

Keywords: FIRST-EVER ACUTE CEREBRAL ISCHEMIC STROKE, POST-STROKE SPASTICITY, EXCITATOTY AND INHIBITORY NEURO AMINO ACIDS

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