Bìol. Tvarin, 2016, vol. 18, no. 1, pp. 87–92

EFFICIENCY OF ANTIPARASITIC DRUGS FROM MACROCYCLIC LACTONES GROUP AND IMMUNOMODULATOR IN CARP INFECTED BY LERNEOSES

Yu.  Loboyko1, М. Danko2, V. Stybel1

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1Lviv National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytskyj,
50 Pekarska str., Lviv 79010, Ukraine

2State Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives,
11 Donetska str., Lviv 79019, Ukraine

The paper presents the results of studies conducted to determine the therapeutic efficiency of antiparasitic drugs from the macrocyclic lactones group “Brovermeсtyn-granulate”, “Emameсtyn benzoate” and immunomodulator “Avesstym”. The material for the study of the drug efficiency was the earlings of Lyubin scaly carp spontaneously infested by ectoparasites Lernaea cyprinacea. For experiments we used drugs “Brovermectyn-granulate” (serial production development at SMF “Brovafarma”; 1 g of the drug contains active substance (AS) ivermectin — 3.5 mg, tocopherol acetate— 20 mg) and «Emamectyn benzoate» (production of King Quenson Industry Group; 1 g of the drug contains AS emamectyn benzoate — 50 mg) and immunomodulator «Avesstym» (synthesized in the laboratory of toxicological and inorganic chemistry of Zaporizhia State Medical University; 1 g contains AS morpholin 2-[5-(pirydyn-4-yl)-1,2,4-triazoles-3-iltio]acetate — 10 mg).

It was established that the use of antiparasitic drugs from the group of macrocyclic lactones “Brovermeсtyn-granulate” and “Emameсtyn benzoate” ensures a high therapeutic efficacy for spontaneous lerneoses of carp. “Brovermeсtyn-granulate” when used twice at a dose of 60 mg/kg showed extension effectiveness and intension effectiveness 90 % and 97.5 % respectively. Extension effectiveness and intension effectiveness of «Emamectyn benzoate» applied at a dose of 10.0 mg/kg for seven days were 90 % and 97.7 % respectively. It was proved that complex application of immunomodulator “Avesstym” and antiparasitic drug “Brovermectyn-granulate” in carp infested by lerneoses ensures destruction of pathogens invasion, activation of the immune system, rapid recovery of damaged tissue, improves overall health of fish.

Keywords: CARP, ECTOPARASITES, LERNAEA CYPRINACEA, MACROCYCLIC LACTONES, IMMUNOMODULATOR

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