Bìol. Tvarin, 2016, vol. 18, no. 1, pp. 9–16

GLUCOCOTICOSTEROID ACTIVITY OF THE ADRENAL GLANDS OF COWS DURING PREGNANCY AND FOR ORTHOPEDIC, OBSTETRIC AND GYNECOLOGICAL PATHOLOGIES

S. Vlasenko

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Bila Tserkva National Agrarian University,
8/1 Soborna sq., Bila Tserkva 09111, Ukraine

Endocrine research was performed by ELISA. Cortisol was determined in the blood serum of cows during pregnancy, 3–5 day after childbirth, at acute postpartum metritis, ovarian hypofunction, persistence of corpus luteum, luteal cysts and oophoritis. Thus, the control animals had healthy limbs, and the research ones had the pulp and interdigital vault skin ulcers, cellulitis edges, purulent pododermatitis.

It has been established that cortisol dynamics in cows during pregnancy and after childbirth underwent significant alteration and was characterized by alternating periods of increase and decrease of hormone. In second and third months it was 1.41±0.45 and 1.22±0.25 mcg/dl. During the fourth month we observed its double increase, and the on fifth month it reached a maximum value — 3.02±0.44 mcg/dl. The sixth month of pregnancy was characterized by a sharp decrease in the concentration by 46.4 % — to 1.62±0.17 mcg/dl, and in the next two months there were minor fluctuations. Preparation for childbirth ran with the level of cortisol lowered 1.7 times, however, during the first 3–5 days of puerperal period the increase to 1.63±0.45 mcg/dl was noted. The development of acute postpartum metritis predetermined increase in cortisol concentrations 2.3 times, persistent corpus luteum — 7.2 times, oophoritis — 6 times.

For purulent necrotic processes in the distal extremities in all patients cows, regardless of reproductive status, hormone concentration was higher by 20,4–67,7 % compared to control animals. In addition, the difference between the rates was negligible during pregnancy that graded them within 2.63±0.31–3.99±0.46 mcg/dl. In cases of associated orthopedic pathology in cows after birth and inflammation of the uterine the contents of cortisol in serum underwent a likely increase 2.5 times compared to clinically healthy animals and reached 4.12±1.08 mcg/dl.

Keywords: COW, CORTISOL, IMMUNOFERMENTAL ANALYSIS, PREGNANCY, POSTNATAL PERIOD, ORTHOPEDIC PATHOLOGY, METRITIS, HYPOFUNCTION OF OVARIES, HYPOTROPHIC OF OVARIES, PERSISTENS CORPUS LUTEUM, LUTEAL CYST, OOPHORITIS

1. Jafarov M. H., Zaicev S. U., Maksimov V. I. Steroids. St.-Petersburg, Lanj, 2010, 288 p. (in Russian)
2. Serife Mehlika Kuskonmas, Neslihan Bascil Tütüncü. Sepsiste Steroid Kullanimi. Turkish journal of Endocrinology and Metabolism, 2013, vol. 17, pp. 121–124.
3. Grossman A., Johannsson G., Quinkler M., Zelissen P. Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. Eur. Jornal Endocrinology, 2013, vol. 169, no 6, pp. 165–175. https://doi.org/10.1530/EJE-13-0450
4. Wirth M. M., Meier E. A., Fredrickson B. L., Schultheiss O. C. Relationship between salivary cortisol and progesterone levels in humans. Biological Psychology, 2007, vol. 74, pp. 104–107. https://doi.org/10.1016/j.biopsycho.2006.06.007
5. Peter J. Fuller, Adrenal Diagnostics: An Endocrinologist’s Perspective focused on Hyperaldosteronism. J. Clin. Biochem. Rev., 2013, vol. 34, pp. 111–116.
6. Vlasova U. U. The role of the hypothalamic-pituitary-adrenal system in the pathogenesis of exogenously-constitutional obesity. Endocrinology, 2009, vol. 24, pp. 1610–1614. (in Russian)
7. Dreval A. V. Diagnosis of patients subclinical hypercorticism among alimentary obesity. Endocrinology, 2015, vol. 8, pp. 425–427. (in Russian)
8. Zografos G. N., Perysinakis I., Vassilatow E. Subclinical Cushing’s syndrome:current concepts and trends. J. Hormones (Athens), 2014, vol. 13, no. 3, pp. 323–337. https://doi.org/10.14310/horm.2002.1506
9. Fleseriu M. Recent advances in the medical treatment of Cushing’s disease. F1000 — Prime Reports, 2014, vol. 6, no. 18. DOI: 10. 12703/P6–18 (in USA)
10. Reznik Y., Bertherat J., Borson-Chazot F., Brue T., Chanson P., Cortet-Rudelli C., Delemer B., Tabarin A., Bisot-Locard S., Verges B. Management of hyperglycaemia in Cushing’s disease: experts’ proposals on the use of pasireotide. Diabetes Metab., 2013, vol. 39, pp. 34–41. https://doi.org/10.1016/j.diabet.2012.10.005
11. Dillard T. H., Gultekin S. H., Delashaw J. B., Yedinak C. G., Neuwelt E. A., Fleseriu M. Temozolomide for corticotroph pituitary adenomas refractory to standard therapy. Pituitary, 2011, vol. 14, pp. 80–91. https://doi.org/10.1007/s11102-010-0264-1
12. Bertagna X., Guignat L: Approach to the Cushing’s disease patient with persistent/recurrent hypercortisolism after pituitary surgery. J. Clin. Endocrinol. Metab., 2013, vol. 98, pp. 1307–1318. https://doi.org/10.1210/jc.2012-3200
13. Davis E. P., Sandman C. A. The Timing of Prenatal Exposure to Maternal Cortisol and Psychosocial Stress Is Associated With Human Infant Cognitive Development. Child Development, 2010, vol. 81, no. 1, pp. 131–148. https://doi.org/10.1111/j.1467-8624.2009.01385.x
14. Tatarchuk T. F. Stress and reproductive function of woman. International endocrinology journal, 2006, vol. 3, no. 5, pp. 2–9. (in Ukrainian)
15. Tatarchuk T. F., Burlaka O. F., Tutchenko T. M., Ganzij I. U. Influence of psychosocial maladjustment to the reproductive health of adolescent girls. Reproductive health of women, 2008, vol. 5, no. 39, pp. 180–183. (in Ukrainian)
16. Dovgikova I. V. Cortisol during pregnancy. Bulletin VSNC SORAMN, 2010, vol. 6, no. 76, p. 1, pp. 226–229. (in Russian)
17. Dovgikova I. V., Lucenko M. T., Andrievskaja I. A. Content of cortisol in platsente during exacerbations of herpes infection in the early term pregnancy. Bulletin physiology and respiratory pathology, 2012, no. 44, pp. 69–74. (in Russian)
18. Alexander B. T. Fetal programming of hypertension. J. Physiol. Regylatory Integrative Comp. Physiol, 2006, vol. 290, no. 1, pp. 1–10. https://doi.org/10.1152/ajpregu.00417.2005
19. Myatt L. Placental adaptive responses and fetal programming. J. Physiol., 2006, vol. 572, no 1, pp. 25–30. https://doi.org/10.1113/jphysiol.2006.104968
20. Nefedova Z. V., Soboleva M. K. Evaluation indicators renin-angiotensin-aldosterone system, electrolyte metabolism and sekretsyy cortisol in the blood in children and adolescents with hypertension arteryal. Bulletin SO RAMN, 2011, vol. 31, no. 1, pp. 64–68. (in Russian)
21. Riecher-Rossler A., Steiner M. Perinatal stress, mood and anxiety disorders: from bench to bedside. Bassl, Karger, 2005, 199 p. https://doi.org/10.1159/isbn.978-3-318-01176-0
22. Sevrukov A. V. Contents hormones in the blood of dogs at alimentary stress. Kuban Veterinary, 2014, no. 6, pp. 12–16. (in Russian)
23. Deeva A. V., Polzunova M. V., Andreeva M. V., Zaiceva M. L. Prevention of transport stress horses. Veterinary, 2005, no. 5, pp. 16–19. (in Russian)
24. Ermakova N. V. Prevention tehnology stress in cows with correlation of seasons. Proc. 8th Int. Conf. “Science Days”. Prague, 2012, pp. 33–36. (in Czech)
25. Nezdanov A. G. Illness of reproduction organs in large horned cattle livestock in modern achievements of reproductive endokrynolohy and patobyochymystry. Proc. Trudy. “Modern diagnostic problems treatment and prophilaktic infektional deseases animals and poultry”. Ekaterinburg, 2008, pp. 350–359. (in Russian)
26. Vlasov S. A. Fetoplacental insufficiency in cows (diagnostics, prophylactic). Dr. veterinary sci. diss. Voronezh, 2000. 284 p. (in Russian)

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